Thermo Fisher Scientific RGS13 Polyclonal Antibody
RGS13 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 마우스에 반응합니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 1–159 of RGS13 (Uniprot ID: O14921) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_11157058 |
Product Specific Information
- Recommended positive controls: Jurkat, Raji, NCI-H929, human RGS13-transfected 293T cells
- Predicted reactivity: Mouse (84%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
RGS13 is the smallest member of the mammalian RGS (regulators of G protein-signaling) family, homologous to yeast SST2 and C. elegans egl-10 proteins. RGS proteins act as GTPase-activating proteins (GAPs) for Ga subunits, attenuating G protein-mediated signaling.
RGS13 is abundant in human tonsil, thymus, lung, lymph node, and spleen. It regulates Gai, Gaq, and Gas coupled signaling cascades, acting as a GAP for Gai and Gao. The protein inhibits MAPK activity induced by Gai- or Gaq-coupled receptors and attenuates GTPase-deficient Gaq (GaqQL) mediated cAMP response element activation.
The human RGS13 gene is located on chromosome 1q31.2.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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