Thermo Fisher Scientific DNA ligase IV Recombinant Rabbit Monoclonal Antibody (JM64-32)
Recombinant rabbit monoclonal antibody recognizing human DNA ligase IV. Suitable for WB, IHC(P), and ICC/IF. Offers high specificity, lot-to-lot consistency, and animal origin-free formulation. Supplied as 1 mg/mL liquid, Protein A purified, with TBS b...
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | – |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | 1 publication available |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM64-32 |
| Immunogen | Recombinant protein within Human DNA Ligase IV (aa 484–705) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810052 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The specific antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
DNA ligase IV is an enzyme that joins single-strand breaks in double-stranded DNA in an ATP-dependent reaction. It plays an essential role in V(D)J recombination and DNA double-strand break (DSB) repair via nonhomologous end joining (NHEJ).
This protein forms a complex with XRCC4 and interacts with DNA-dependent protein kinase (DNA-PK), both crucial for NHEJ.
The crystal structure of the DNA ligase IV–XRCC4 complex has been resolved.
Defects in this gene cause LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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