Thermo Fisher Scientific HLA-DR/DP Monoclonal Antibody (MEM-136), APC

Thermo Fisher Scientific HLA-DR/DP Monoclonal Antibody (MEM-136), APC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• FITC
• PE
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with alpha/beta dimer as well as with dissociated beta-subunit. DR and DP are isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).

Target Information

HLA-DRA is one of the HLA class II alpha chain paralogues. This molecule is a heterodimer consisting of alpha and beta chains, both membrane-anchored. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages).
The alpha chain is approximately 33–35 kDa and its gene contains five exons: exon 1 encodes the leader peptide, exons 2 and 3 encode extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail. DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, lacking polymorphisms in the peptide-binding region.

HLA and MHC antibodies play a significant role in immunopeptidomics, facilitating identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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