Thermo Fisher Scientific DACT3 Polyclonal Antibody
DACT3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. IHC, ICC, ELISA 등 다양한 응용에 적합하며, 인간, 마우스, 랫트 반응성. Protein A 정제, 1 mg/mL 액상 형태로 제공. 연구용 전용 시약.
- 카탈로그번호
- BS-11837R
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific DACT3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human DACT3, amino acids 575–629 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in postnatal tissues such as the brain.
Dact3, a member of the Dact protein family, was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and adult brain.
Recent evidence shows that Dact3 acts as a negative regulator of Wnt/β-catenin signaling and is repressed at the transcriptional level in colorectal cancer, associated with bivalent histone modifications. This repression can be reversed by pharmacological agents targeting both histone methylation and deacetylation, suggesting Dact3 may be a potential therapeutic target. At least three isoforms of Dact3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.