Thermo Fisher Scientific HAS3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human HAS3 protein. Suitable for Western blot and ELISA applications. Reacts with human, mouse, and rat samples. Affinity-purified, liquid form, stored at -20°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 67–281 of human HAS3 (NP_6195151) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806623 |
Product Specific Information
Immunogen sequence:
HRRMRRAGQA LKLPSPRRGS VALCIAAYQE DPDYLRKCLR SAQRISFPDL KVVMVVDGNR QEDAYMLDIF HEVLGGTEQA GFFVWRSNFH EAGEGETEAS LQEGMDRVRD VVRASTFSCI MQKWGGKREV MYTAFKALGD SVDYIQVCDS DTVLDPACTI EMLRVLEEDP QVGGVGGDVQ PPGKGMAVED DQVQAAQVRA TEAWSVHQRH VSREQPositive Samples: A-549, HL-60, SKOV3, SW480, Mouse heart, Rat liver, Rat heart
Cellular Location: Membrane, Multi-pass membrane protein
Target Information
HAS1, HAS2, and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins. HA is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by β-1,3 and β-1,4 glycosidic bonds.
The three HAS genes show distinct expression patterns during development and have different roles in HA matrix formation. HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular-weight HA.
HAS3 is the most active isoform in adults and produces both secreted and cell-associated forms of hyaluronan. It plays a critical role in regulating hyaluronan synthesis in the epidermis. IFN-γ upregulates HAS3 mRNA, while TGFβ downregulates its transcript levels. The human HAS3 gene maps to chromosome 16q22.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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