Thermo Fisher Scientific CDCA7L Monoclonal Antibody (OTI3B5), TrueMAB
CDCA7L 단백질을 인식하는 마우스 단클론 항체로, Western blot과 IHC(파라핀 절편)에 사용 가능. 인간 시료에 반응하며, 동결건조 형태로 제공. 재구성 후 1 mg/mL 농도로 사용 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–337 of human CDCA7L produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Cell division cycle-associated 7-like protein (CDCA7L, also known as RAM2) is a transcription factor involved in transcriptional regulation and apoptotic signaling pathways.
It acts as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to its promoter region.
CDCA7L plays an oncogenic role in mediating the transforming effect of MYC in medulloblastoma cells.
It may function downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3, CCND1/cyclin D1, and E2F1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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