Thermo Fisher Scientific PIK3C2B Monoclonal Antibody (OTI3B1), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Class II PI3 kinases, including PIK3C2B, phosphorylate the 3 position of PI or PI4P. Although less studied than class I PI3 kinases, class II enzymes are associated with receptor-mediated cellular processes such as insulin signaling, neuronal survival, and growth factor signaling.
Protein kinases transfer phosphate groups from donors (typically ATP) to acceptor amino acids in substrate proteins, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, apoptosis, and differentiation.
The protein kinase family, with over 500 gene products, is one of the largest in eukaryotic cells and is classified into eight major groups based on catalytic domain sequence comparison.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.