Thermo Fisher Scientific Synaptophysin Polyclonal Antibody
Synaptophysin 단백질을 인식하는 Rabbit Polyclonal 항체로, 신경말단 및 신경내분비 종양 마커 연구에 적합. WB, IHC, ICC 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성 확인. 고순도 항원 친화 크로마토그래피 정제.
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Thermo Fisher Scientific Synaptophysin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:50,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 170–313 of Human Synaptophysin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7) with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544762 |
Product Specific Information
- Recommended positive controls: human brain, mouse brain, rat brain, mouse small intestine, LNCaP cells
- Predicted reactivity: Mouse (94%), Rat (95%), Rhesus Monkey (97%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Synaptophysin is a calcium-binding integral membrane glycoprotein found in presynaptic vesicles of nearly all neurons. It contains four transmembrane domains and forms complexes with dynamin under high calcium conditions, indicating a role in synaptic vesicle endocytosis. Synaptophysin is involved in regulating short-term and long-term synaptic plasticity and serves as a key marker for nerve terminals and neuroendocrine tumor differentiation. Mutations in the gene are associated with X-linked mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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