Thermo Fisher Scientific CDKN1A Monoclonal Antibody (OTI6G2), TrueMAB
인간 CDKN1A(p21) 단백질을 인식하는 마우스 단일클론 항체. Western blot에 적합하며, p53 경로 및 세포주기 조절 연구에 유용. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CDKN1A Monoclonal Antibody (OTI6G2), TrueMAB
Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6G2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 2–164 of human CDKN1A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53.
P21 plays a crucial role in the cellular response to genotoxic stress and is a major transcriptional target of p53.
In the nucleus, p21 binds and inhibits CDK1 and CDK2, blocking the transition from G1 to S phase or G2 to mitosis after DNA damage, allowing DNA repair.
In the cytoplasm, p21 has anti-apoptotic effects, binding and inhibiting caspase 3, ASK1, and JNK.
P21 exhibits dual roles in carcinogenesis—acting as a tumor suppressor and oncogene depending on context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.