Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI1E5), TrueMAB
Thermo Fisher Scientific의 ACY1 단클론 항체(OTI1E5)는 인간 ACY1 단백질을 인식하는 Mouse IgG1 항체로, Western blot 및 유세포분석(Flow Cytometry)에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적이며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E5 |
| Immunogen | Full length human recombinant protein of human ACY1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids. The gene is located on chromosome 3p21.1, a region often reduced to homozygosity in small-cell lung cancer (SCLC), where its expression is frequently diminished or absent. The human aminoacylase-1 sequence shows high homology with the porcine enzyme and represents the first member of a new zinc-binding enzyme family. Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder characterized by CNS defects and elevated urinary N-acetylated amino acids. Multiple transcript variants exist due to alternative splicing, and read-through transcription occurs with the upstream ABHD14A gene. A related pseudogene is found on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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