Thermo Fisher Scientific Cystatin SA Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The cystatin superfamily is a well-established family of cysteine protease inhibitors.
Cystatins A and B (type 1) are mainly intracellular, while cystatins C, D, E/M, F, G, S, SN, and SA (type 2) are extracellular.
Kininogens are type 3 cystatins found in intravascular proteins.

All true cystatins inhibit cysteine peptidases of the papain family (e.g., cathepsins) and some also inhibit legumain family enzymes.
Cystatin SA, S, and SN are primarily found in saliva, while Cystatin S and SN can also be expressed in tears, urine, and seminal fluid.
Cystatin C is expressed in brain, thymus, ovary, epididymis, and vas deferens.
Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F regulate cathepsin inhibition.

The fetuins, part of the cystatin superfamily, are secretable proteins involved in osteogenesis, bone resorption, insulin and hepatocyte growth factor receptor regulation, and systemic inflammation response.
High molecular weight kininogen (Kininogen HC) and low molecular weight kininogen (Kininogen LC) both inhibit thrombin- and plasmin-induced thrombocyte aggregation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.