Thermo Fisher Scientific Ki67 Monoclonal Antibody (OTI15A4), TrueMAB
Ki-67 단백질을 표적하는 마우스 단일클론 항체로, 세포 증식 지표 분석에 사용. Western blot 및 파라핀 조직 면역조직화학(IHC)에 적합. 무보존제, 동결건조 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Ki67 Monoclonal Antibody (OTI15A4), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI15A4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1160–1493 of human MKI67 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Ki-67 is a nuclear protein expressed during various stages of the cell cycle—late G1, S, G2, and M phases. It associates with euchromatin at the perichromosomal layer, centromeric heterochromatin, and nucleolus through its forkhead-associated (FHA) domain.
Ki-67 expression varies by cell cycle phase: perinucleolar at G1, nuclear matrix at G2, and chromosomal during M phase.
It serves as a proliferation marker since it is absent in G0 cells but increases from G1 through mitosis.
Ki-67 antibodies are valuable for determining the proliferative fraction in neoplasms, with prognostic significance comparable to thymidine-labelling index.
Low Ki-67 index correlates with low-grade tumors.
Commonly used as a neuronal marker of cell cycling and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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