Thermo Fisher Scientific Ki67 Monoclonal Antibody (OTI15A4), TrueMAB

Thermo Fisher Scientific Ki67 Monoclonal Antibody (OTI15A4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Ki-67 is a nuclear protein expressed during various stages of the cell cycle—late G1, S, G2, and M phases. It associates with euchromatin at the perichromosomal layer, centromeric heterochromatin, and nucleolus through its forkhead-associated (FHA) domain.
Ki-67 expression varies by cell cycle phase: perinucleolar at G1, nuclear matrix at G2, and chromosomal during M phase.
It serves as a proliferation marker since it is absent in G0 cells but increases from G1 through mitosis.
Ki-67 antibodies are valuable for determining the proliferative fraction in neoplasms, with prognostic significance comparable to thymidine-labelling index.
Low Ki-67 index correlates with low-grade tumors.
Commonly used as a neuronal marker of cell cycling and proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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