Thermo Fisher Scientific IGF1R (CD221) Monoclonal Antibody (1H7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-10 µg/mL

-

ChIP assay (ChIP)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1H7

Immunogen

Purified human placental IGF-1 receptors. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IGF1R (CD221),uniProtId:P08069-1,ncbiNodeId:9606,antigenRange:1-1367,antigenLength:1367,antigenImageFileName:MA1-10854_IGF1R_CD221_P08069-1_House_mouse.svg,antigenImageFileNamePDP:MA1-10854_IGF1R_CD221_P08069-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.4 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1075414

Product Specific Information

MA1-10854 detects IGF-1 Receptor from human samples.

MA1-10854 has been successfully used in Western blot applications. Dilute in PBS or medium which is identical to that used in the assay system.

The MA1-10854 immunogen is purified human placental IGF-1 receptors.

Target Information

IGF1R, also known as Insulin-like Growth Factor 1 (IGF-1) Receptor, is a receptor tyrosine kinase activated by IGF-1 and IGF-2. IGFR has been implicated in a variety of cancers. The protein is a tetramer consisting of two alpha, and two beta subunits. The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2. Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136. The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.