Thermo Fisher Scientific IGF1R (CD221) Monoclonal Antibody (1H7)
IGF1R(CD221)을 인식하는 Mouse Monoclonal Antibody(1H7)로 Western blot에 적합. Human 시료에서 반응하며 Protein G로 정제된 액상 형태. PBS(pH7.4) 버퍼에 보존, 무보존제. -20°C 보관, IGF-1 receptor 연구용으로 최적.
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Applications
Western Blot (WB)
- Tested Dilution: 1–10 µg/mL
ChIP assay (ChIP)
- Tested Dilution: Not determined
- Publications: 1 publication available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1H7 |
| Immunogen | Purified human placental IGF-1 receptors |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.4 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1075414 |
Product Specific Information
MA1-10854 detects IGF-1 Receptor from human samples.
It has been successfully used in Western blot applications.
Dilute in PBS or medium identical to that used in the assay system.
The immunogen is purified human placental IGF-1 receptors.
Target Information
IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase activated by IGF-1 and IGF-2.
It plays a role in various cancers. The protein forms a tetramer of two alpha and two beta subunits.
Alpha-subunits bind IGF-1 with higher affinity than IGF-2, inducing conformational change and autophosphorylation at residues 1134, 1135, and 1136.
Activated IGF-1R phosphorylates substrate proteins, triggering RAS/RAF/MAPK pathways (ERK, p38, JNK) that promote gene transcription and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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