Thermo Fisher Scientific Phospho-STAT2 (Tyr690) Polyclonal Antibody
STAT2 단백질의 Tyr690 인산화를 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(F)에서 검증됨. Human에 반응하며, Rhesus Monkey에도 예측 반응. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 용액 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of Human STAT2 (phospho Tyr690). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.23 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736425 |
Product Specific Information
- Positive Control: HeLa (starvation for 16 hr and 100 ng/mL hIFN-alpha treatment for 5 min)
- Predicted Reactivity: Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and form homo- or heterodimers that translocate to the nucleus to act as transcription activators.
In response to interferon (IFN), STAT2 forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), acting as a transactivator but lacking direct DNA-binding ability.
Transcription adaptor P300/CBP (EP300/CREBBP) interacts specifically with STAT2 and is thought to be involved in blocking IFN-alpha response by adenovirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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