Thermo Fisher Scientific Desmoplakin Polyclonal Antibody
Desmoplakin 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC(P), ELISA에 적합하며, Affinity Chromatography로 정제되었습니다. 세포 접합부 및 세포골격 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 2609–2830 of human Desmoplakin (NP_0044062) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.42 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805386 |
Product Specific Information
- Positive Samples: HepG2
- Cellular Location: Cell junction, Cytoplasm, Cytoskeleton, Desmosome
Immunogen sequence:
FSDTLEESSP IAAIFDTENL EKISITEGIE RGIVDSITGQ RLLEAQACTG GIIHPTTGQK LSLQDAVSQG VIDQDMATRL KPAQKAFIGF EGVKGKKKMS AAEAVKEKWL PYEAGQRFLE FQYLTGGLVD PEVHGRISTE EAIRKGFIDG RAAQRLQDTS SYAKILTCPK TKLKISYKDA INRSMVEDIT GLRLLEAASV SSKGLPSPYN MSSAPGSRSG SR
Target Information
Desmoplakin (DSP) is a major high molecular weight protein of desmosomes. It plays a critical role in organizing desmosomal cadherin-plakoglobin complexes into plasma membrane domains and anchoring intermediate filaments to desmosomes.
Mutations in Desmoplakin are associated with Keratoderma and cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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