Thermo Fisher Scientific p14ARF Recombinant Rabbit Monoclonal Antibody (ARC1144)
Thermo Fisher Scientific의 p14ARF 재조합 토끼 단클론 항체(ARC1144)는 인간 p14ARF 단백질(aa 1-100)에 특이적입니다. Western blot과 면역세포화학(ICC/IF)에 최적화되어 있으며, 고순도 액상 형태로 제공됩니다. 암 연구 및 세포주기 조절 연구에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1144 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human p14ARF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.4 mg/mL |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849523 |
Target Information
The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and ARF (p14ARF in human, P19ARF in mouse). These proteins interact with retinoblastoma protein and p53 tumor suppressors, respectively, playing key roles in cell senescence, cell cycle control, and tumor suppression. p14ARF can induce both G1 and G2 phase arrest in a p53-dependent manner. Functional differences between mouse and human ARF proteins may contribute to species-specific tumor susceptibility.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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