Thermo Fisher Scientific KPNA2 Recombinant Rabbit Monoclonal Antibody (ARC1227)
Thermo Fisher의 KPNA2 재조합 토끼 단클론 항체(ARC1227)는 인간, 마우스, 랫트 시료에 반응하며 Western blot 및 ELISA에 적합합니다. HEK293 세포에서 발현된 IgG 형 항체로, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1227 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human KPNA2 (UniProt ID: P52292) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849520 |
Product Specific Information
Immunogen sequence:
MSTNENANTP AARLHRFKNK GKDSTEMRRR RIEVNVELRK AKKDDQMLKR RNVSSFPDDA TSPLQENRNN QGTVNWSVDD IVKGINSSNV ENQLQATQAA
Target Information
The import of proteins into the nucleus involves two main steps:
- Energy-independent docking of the protein to the nuclear envelope.
- Energy-dependent translocation through the nuclear pore complex.
Imported proteins require a nuclear localization sequence (NLS), typically composed of short basic amino acid regions. Proteins involved in the nuclear import process include importin and its yeast homolog SRP1, which bind to the NLS.
KPNA2 interacts with the NLSs of DNA helicase Q1 and SV40 T antigen, suggesting its role in the nuclear transport of proteins and potentially in VJ recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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