Thermo Fisher Scientific CD14 Monoclonal Antibody (HCD14-61D3)
인간 CD14 단백질을 인식하는 Mouse IgG1 단일클론 항체로, IHC(P) 및 유세포분석에 적합합니다. 단백질 A로 정제된 액상형 제품이며, 0.5 mg/mL 농도로 제공됩니다. 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 0.5–5 µg/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HCD14-61D3 |
| Immunogen | Mice were immunized with cultured human peripheral blood monocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human peripheral monocytes
- Cellular location: Membrane, Cytoplasmic
Target Information
CD14 is a 55 kDa GPI-anchored glycoprotein expressed on the surface of mature monocytes, macrophages, and neutrophils. It functions as a multifunctional lipopolysaccharide receptor and is released into serum as both secreted and enzymatically cleaved forms. CD14 binds lipopolysaccharides in a reaction catalyzed by lipopolysaccharide-binding protein (LBP). The soluble form (sCD14) discriminates structural differences among lipopolysaccharides and plays a role in neutralizing serum lipopolysaccharides. CD14 also binds apoptotic cells and influences allergic, inflammatory, and infectious processes. Alternative splicing results in multiple transcript variants encoding the same isoform. Diseases associated with CD14 dysfunction include Mycobacterium chelonae infection and Croup.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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