Thermo Fisher Scientific CD51 Monoclonal Antibody (HCD51-10C4)
인간 CD51(Integrin αV)을 인식하는 Mouse IgG1 단클론 항체입니다. IHC(P) 및 유세포분석(Flow Cytometry)에 적합하며, 단백질 A로 정제된 액상 형태로 제공됩니다. 인간 멜라노마 세포를 면역원으로 사용하였으며, 세포막 및 세포질에서 발현을 검출합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | 0.5–5 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HCD51-10C4 |
| Immunogen | Mice were immunized with cultured human melanoma cells (Integrin alpha V, CD51, UniProt ID: P06756-1, antigen range: 1–1048 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human melanoma
- Cellular location: Membrane, Cytoplasmic
Target Information
Gene: ITGAV (Integrin alpha V)
Integrins are heterodimeric integral membrane proteins composed of an alpha and a beta chain. The integrin alpha V chain undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains (β1, β3, β5, β6, and β8) to form distinct integrins. Among these, the αVβ3 integrin, also known as the Vitronectin Receptor (VNR), is well-studied for its role in cell adhesion and signal transduction. Integrins are key mediators of cell–matrix interactions and intracellular signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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