Thermo Fisher Scientific Phospho-ATM (Ser1987) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

Phospho-ATM (Ser1987) Polyclonal Antibody detects endogenous levels of ATM only when phosphorylated at Ser1987.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer.

The ATM gene encodes a protein in the phosphoinositide 3-kinase (PI3K) superfamily. Unlike typical PI3Ks, ATM phosphorylates proteins rather than lipids and regulates downstream targets such as P53, Mdm2, BRCA1, and SMC1.
ATM plays a key role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. Its C-terminal region shares homology with catalytic domains of PI3 kinases.

Upon DNA damage, ATM undergoes autophosphorylation and activation, initiating kinase cascades that control cell cycle, apoptosis, and DNA repair.
ATM dysfunction leads to hypersensitivity to ionizing radiation, impaired DNA synthesis inhibition, and delayed p53 induction.
Studies also link ATM to apoptosis regulation via the E2F1 pathway involving Nbs1 and Chk2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.