Thermo Fisher Scientific Phospho-p130 (Ser639) Polyclonal Antibody
인산화된 RBL2(p130) Ser639 잔기를 특이적으로 인식하는 폴리클로날 항체로, Western blot에 적합합니다. 사람, 생쥐, 랫트 시료에 반응하며, 고순도의 Affinity chromatography 정제 제품입니다. PBS/glycerol 완충액에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RBL2 (Phospho-Ser639) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2662148 |
Product Specific Information
Phospho-RBL2 (Ser639) Polyclonal Antibody detects endogenous levels of RBL2 only when phosphorylated at Ser639.
Target Information
RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of cell division entry. It is directly involved in heterochromatin formation by maintaining chromatin structure and stabilizing histone methylation. RBL2 recruits histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression and control of histone H4 Lys20 trimethylation. It likely acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters and serves as a potent inhibitor of E2F-mediated trans-activation, associating preferentially with E2F5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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