Thermo Fisher Scientific Phospho-CHK2 (Ser379) Polyclonal Antibody
인간 CHK2의 인산화된 Ser379를 특이적으로 검출하는 폴리클로날 항체. Western blot에 적합하며 내인성 인산화 CHK2 단백질을 감지. 액상 형태, 농도 1 mg/mL, -20°C 보관. 암 연구 및 DNA 손상 경로 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Chk2 (Phospho-Ser379) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2665306 |
Product Specific Information
Phospho-CHK2 (Ser379) Polyclonal Antibody detects endogenous levels of CHK2 only when phosphorylated at Ser379.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in the Chk2 gene linked to Li-Fraumeni syndrome, a familial cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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