Thermo Fisher Scientific Cdc6 Polyclonal Antibody
Cdc6 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. DNA 복제 개시 관련 단백질 연구용으로 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CDC6 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.36 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2735620 |
Product Specific Information
- Positive Control: Jurkat, HeLa, HeLa (10 mM Hydroxyurea treatment for 18 hr), Neuro2A, GL261, C8D30, BCL-1, Raw264.7, C2C12, PC-12, Rat2
- Predicted Reactivity: Bovine (89%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The CDC6 protein is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. It functions as a regulator at the early steps of DNA replication, localizing in the cell nucleus during G1 phase and translocating to the cytoplasm at the start of S phase. This subcellular translocation is regulated through phosphorylation by Cdks. Transcription of this protein is regulated in response to mitogenic signals via E2F transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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