Thermo Fisher Scientific DUT Polyclonal Antibody
Thermo Fisher Scientific의 DUT Polyclonal Antibody는 인간 DUT 단백질을 인식하는 Rabbit IgG 항체입니다. Western blot에 적합하며, 고순도의 Protein G 정제 방식으로 제조되었습니다. 세포 내 dUTP 대사 연구에 활용됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides, KLH conjugated, corresponding to residues 25–44 and 113–130 of human DUT-N |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2093171 |
Product Specific Information
- Suggested positive control: antigen standard for DUT (transient overexpression lysate), HeLa whole cell extract, HeLa.
Target Information
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate.
This reaction serves two cellular purposes:
- Providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication.
- Limiting intracellular pools of dUTP.
Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death.
Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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