Thermo Fisher Scientific FRMPD4 Polyclonal Antibody
Human FRMPD4 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS와 글리세롤 버퍼에 보관됩니다. 신경세포 내 수상돌기 밀도 연구에 활용 가능합니다.
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Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FRMPD4. Recombinant protein control fragment (Product #RP-102448) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641748 |
Product Specific Information
Immunogen sequence:
PETVLFFSGK VEPPHSSHED LTDGLSTRSF CHPEPHERDA LLAGSLNNTL HLSNEQERGD WPGEAPKPPE PYSHHKAHGR SKHPSGSNTQ PGMESDPYEA EDFVCDYHLE ML
Highest antigen sequence identity to the following orthologs:
- Mouse: 75%
- Rat: 79%
Target Information
The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain.
FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions.
Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width; conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology.
The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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