Thermo Fisher Scientific IGF1R alpha Polyclonal Antibody
IGF1R 알파 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, Flow cytometry에 적합합니다. 인간에 반응하며, 마우스와 랫에서도 반응이 예측됩니다. 고순도 정제 및 안정적 보관이 가능한 연구용 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 51–77 amino acids from the N-terminal region of human IGF1R |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.8 mg/mL |
| Purification | Size-exclusion - Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542110 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IGF1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosine phosphorylation of multiple substrates that function as signaling adapter proteins.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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