Thermo Fisher Scientific CRHBP Monoclonal Antibody (C11)
CRHBP 단백질을 인식하는 C11 클론의 Mouse Monoclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. Protein A/G로 정제된 액상 항체로, -20°C 보관. 스트레스 반응 관련 CRHBP 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C11 |
| Immunogen | Recombinant protein Corticotropin Releasing Hormone Binding Protein (CRHBP), corresponding to amino acids 25–322 of the target protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899055 |
Target Information
Response to stress in mammals requires an intact hypothalamic-pituitary-adrenal axis. The proximal part of the response is mediated by secretion of corticotropin-releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus.
CRH is a 41 amino acid peptide derived by enzymatic cleavage from a 191 amino acid preprohormone. It is produced not only in the hypothalamus but also in peripheral tissues such as T lymphocytes and is highly expressed in human placenta.
Glucocorticoids stimulate placental CRH synthesis and secretion in primary cultures of human placenta, contrasting with glucocorticoid suppression of CRH expression in the hypothalamus.
Human plasma contains a CRH-binding protein (CRH-BP, also known as CRF-BP) which inactivates CRH and may prevent inappropriate pituitary-adrenal stimulation during pregnancy. The CRF-BP gene maps to human chromosome 5q11.2–q13.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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