Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (TRP/816)

Applications and Tested Dilution

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 activation induces transcription of genes such as p21waf1, leading to G1 or G2/M arrest.

Structurally, p53 consists of:

• N-terminal transactivation domain
• Central DNA-binding domain
• Oligomerisation domain
• C-terminal regulatory domain

Phosphorylation at Ser15 is critical for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells, contributing to tumor suppression and influencing aging and oxidative stress responses. Mutations in TP53 are common in many cancers and can lead to loss of tumor suppressor activity. Germline mutations are linked to cancer-prone syndromes such as Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.