Thermo Fisher Scientific Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (Chk1S317-F10), APC
Phospho-Chk1 (Ser317) 인산화 단백질을 특이적으로 인식하는 재조합 토끼 단클론 항체. Flow Cytometry에 최적화되어 있으며, APC 형광 표지로 651/660 nm에서 검출 가능. HEK293 세포 발현, Protein A/G 정제, 4°C 보관.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Chk1S317-F10 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896939 |
Additional Formats
- Unconjugated (MA5-37001)
- FITC (MA5-37003)
- PE (MA5-37002)
- Custom conjugation available upon request
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised.
CHK1 is a key mediator in the DNA damage-induced checkpoint network and functions to ensure genomic integrity upon genotoxic stress.
When the G2 or S checkpoint is abrogated by inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, whereas normal cells remain arrested in G1 phase.
Therefore, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer therapy, making Chk1 an attractive target, especially since about 50% of human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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