Thermo Fisher Scientific Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (Chk1S317-F10)
Phospho-Chk1 (Ser317) 인산화 단백질을 특이적으로 인식하는 재조합 토끼 단클론 항체. 높은 특이성과 재현성을 제공하며, Flow Cytometry 등 다양한 응용에 적합. Human 및 Mouse 시료에 반응. -20°C 보관.
- 판매단위
- pk
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Applications
- Flow Cytometry (Flow): 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Chk1S317-F10 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896936 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase that prevents replication when DNA integrity is compromised. It is a key mediator in the DNA damage-induced checkpoint network and plays a crucial role in maintaining genomic integrity upon genotoxic stress.
Inhibition of CHK1 can lead to mitotic catastrophe and apoptosis in p53-deficient cancer cells, making CHK1 an attractive therapeutic target for cancer treatment, as approximately 50% of all human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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