Thermo Fisher Scientific TORC2 Recombinant Rabbit Monoclonal Antibody (7M2V7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7M2V7

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 594-693 of human TORC2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TORC2,uniProtId:Q53ET0-1,ncbiNodeId:9606,antigenRange:594-693,antigenLength:693,antigenImageFileName:MA5-55347_TORC2_Q53ET0-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55347_TORC2_Q53ET0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: PQDPHTFNHQ NLTHCSRHGS GPNIILTGDS SPGFSKEIAA ALAGVPGFEV SAAGLELGLG LEDELRMEPL GLEGLNMLSD PCALLPDPAV EESFRSDRLQ

Target Information

CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.