Thermo Fisher Scientific TRPV1 Recombinant Rabbit Monoclonal Antibody (10B2A1)
TRPV1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. HEK293 세포에서 발현되었으며 Protein A로 정제되었습니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10B2A1 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 725–839 of human TRPV1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
KLLQVGYTPD GKDDYRWCFR VDEVNWTTWN TNVGIINEDP GNCEGVKRTL SFSLRSSRVS GRHWKNFALV PLLREASARD RQSAQPEEVY LRQFSGSLKP EDAEVFKSPA ASGEK
Target Information
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
TRPV1 is a non-selective cation channel structurally related to TRP family members such as TRPC3 and TRPC6. It is permeable to calcium, magnesium, and monovalent cations (Na⁺, K⁺).
Structurally, TRPV1 contains six transmembrane domains, a P-loop membrane domain, and three ankyrin repeat domains. It is activated by noxious heat and functions as a transducer of painful thermal stimuli.
TRPV1 mediates proton influx and may contribute to intracellular acidosis in nociceptive neurons. Expression is mainly limited to sensory ganglia neurons.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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