Thermo Fisher Scientific CCL4 Monoclonal Antibody (24006), FITC
인간 CCL4 단백질을 특이적으로 인식하는 마우스 단클론 항체로, FITC 형광 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 낮은 교차반응성과 높은 특이성을 가지며, 4°C 암소 보관이 권장됩니다. 연구용 전용 제품입니다.
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Applications
- Flow Cytometry (Flow): 10 µL per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 24006 |
| Immunogen | Sf21-derived recombinant human CCL4/MIP-1 beta (Ala24–Asn92) |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | Buffered saline solution with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609458 |
Additional Formats
- Unconjugated (MA5-23713)
- APC (MA5-23558)
- PE (MA5-23620)
- Custom conjugation available upon request
Product Specific Information
In Western blots, this antibody shows less than 4% cross-reactivity with recombinant human (rh) CCL3/MIP-1 alpha and does not cross-react with recombinant mouse (rm) CCL3/MIP-1 alpha, rmCCL4/MIP-1 beta, rhCXCL8/IL-8, rhCCL5, rhCXCL1, rhCXCL2, or rhCXCL3.
Target Information
CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. It is involved in chemotactic and proinflammatory responses and plays a role in immune homeostasis. CCL4 is produced by macrophages, lymphocytes, and dendritic cells in response to bacterial endotoxins, recruiting various inflammatory cells to sites of infection.
Both CCL4 and CCL3 regulate trafficking and activation of specific immune cell subsets. While both affect monocytes similarly, CCL4 selectively attracts CD4+ lymphocytes, whereas CCL3 attracts CD8+ lymphocytes. CCL4 also acts as a chemoattractant for B cells, eosinophils, and dendritic cells. The processed form of CCL4 can down-modulate CCR5 receptor expression, inhibiting CCR5-mediated HIV-1 entry into T cells. CCL4 binds with high affinity to CCR5 receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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