Thermo Fisher Scientific Septin 2 Polyclonal Antibody
Rabbit 폴리클로날 항체로 Human Septin 2(275–325 aa)에 특이적 결합. Western blot 및 Immunoprecipitation에 사용 가능. Rat, Bovine, Orangutan에서도 반응 예측. 1 mg/mL 액상 형태로 4°C 보관, 1년 안정성 보장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 275 to 325 of Human Septin 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, and Orangutan
Target Information
Septin 2 is a filament-forming cytoskeletal GTPase required for normal organization of the actin cytoskeleton. It contributes to the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, facilitating vesicle transport, and preventing MAP4 binding to tubulin.
It is essential for mitotic progression, forming a scaffold at the midplane of the mitotic spindle to maintain CENPE localization at kinetochores and ensure chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. It also plays roles in ciliogenesis and collective cell movement.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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