Thermo Fisher Scientific HSD3B2 Polyclonal Antibody

Thermo Fisher Scientific HSD3B2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: HeLaS3, Molt-4
• Predicted reactivity: Dog (80%), Cat (81%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

3 beta-hydroxysteroid dehydrogenase (3β-HSD), also known as HSD3B1 or HSDB3, is a bifunctional enzyme essential in the synthesis of all classes of hormonal steroids. Two human 3β-HSD proteins, type I and type II, are expressed by different genes and function in distinct tissues.
Localized to the endoplasmic reticulum membrane and expressed in skin and placenta, the type I enzyme catalyzes the oxidative conversion of Δ5-ene-3β-hydroxy steroids and various ketosteroids.
Defects in the 3β-HSD gene are associated with salt wasting, genital ambiguity, hypogonadism, insulin-resistant PCOS, and increased prostate cancer susceptibility. Congenital deficiency of 3β-HSD activity can result in severe depletion of steroid formation, which may be lethal in young children.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.