Thermo Fisher Scientific Phospho-CaM I (Ser102) Polyclonal Antibody
Phospho-CaM I (Ser102) 폴리클로날 항체로 인간, 마우스, 랫트 반응성. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. Protein A 정제 및 액상 형태, -20°C 보관. 칼모듈린 인산화 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human CaM I around the phosphorylation site of Ser 102 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins, and other proteins by Ca²⁺. It forms a complex with Ca²⁺ to stimulate several protein kinases and phosphatases. Calmodulin, together with CCP110 and centrin, participates in regulating the centrosome cycle and cytokinesis.
Calmodulin is a small, highly conserved calcium-binding protein found in all eukaryotic cells. It binds up to four calcium ions, functioning as an intracellular receptor for calcium signals. Upon calcium binding, it undergoes conformational changes that enhance affinity for target proteins. Calmodulin regulates processes including metabolism, motility, exocytosis, cytoskeletal assembly, and intracellular modulation of cAMP and calcium levels.
This 17 kDa protein contains 149 amino acids and four calcium-binding domains. It plays roles in growth, cell cycle regulation, signal transduction, and neurotransmitter synthesis and release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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