Thermo Fisher Scientific CLSTN1 Recombinant Rabbit Monoclonal Antibody (23GB3725)
Recombinant Rabbit Monoclonal Antibody targeting CLSTN1 for WB and Flow applications. Validated for human and mouse samples. Produced in HEK293F system, purified by affinity chromatography, and supplied in PBS with glycerol. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Flow Cytometry (Flow)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3725 |
| Immunogen | A synthetic peptide of human CLSTN1 (920–981 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion by delaying intracellular APP maturation.
In complex with APBA2 and C99, CLSTN1 prevents C99 interaction with PSEN1 and subsequent cleavage by gamma-secretase, likely by stabilizing the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), possibly by competing with AICD for APBB1 binding. CLSTN1 may modulate calcium-mediated postsynaptic signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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