Thermo Fisher Scientific Phospho-PRAS40 (Ser212) Polyclonal Antibody
PRAS40 단백질의 Ser212 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot 및 IHC(P)에서 검증됨. AKT/mTOR 신호전달 연구에 적합하며, 인산화 상태의 PRAS40 검출에 유용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AKT1S1 (Accession Q96B36), corresponding to amino acid residues around phosphorylated Ser212. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817115 |
Product Specific Information
This antibody detects endogenous levels of PRAS40 only when phosphorylated at Ser212.
Target Information
The Akt signaling pathway contributes to the regulation of apoptosis after various cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia.
AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and the cell cycle, and acts as a negative regulator of autophagy.
Treatment with insulin-like growth factor-1 (IGF1) can induce phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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