Thermo Fisher Scientific HLA-DMB Monoclonal Antibody (6D5)
HLA-DMB 단백질을 인식하는 Mouse monoclonal antibody (Clone 6D5). Western blot 및 ELISA에 적합하며, 인간 시료에 반응. PBS 기반 용액 형태로 제공되며, 보존제 미포함. 연구용으로만 사용 가능.
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- H00003109-M03
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D5 |
| Immunogen | HLA-DMB (NP_002109, 22 a.a. ~129 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
VAHVESTCLL DDAGTPKDFT YCISFNKDLL TCWDPEENKM APCEFGVLNS LANVLSQHLN QKDTLMQRLR NGLQNCATHT QPFWGSLTNR TRPPSVQVAK TTPFNTRE
Target Information
HLA-DMB (major histocompatibility complex, class II, DM beta), also known as D6S221E, RING7, HLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein encoded by the HLA-DMB gene in humans, located on chromosome 6p21.32.
HLA-DMB belongs to the HLA class II beta chain paralogues and forms a heterodimer with an alpha (DMA) chain. This molecule is located in intracellular vesicles and plays a central role in peptide loading of MHC class II molecules by facilitating release of the CLIP peptide.
The beta chain is approximately 26–28 kDa and encoded by six exons. HLA-DMA and HLA-DMB form a functional heterodimer essential for class II antigen presentation.
HLA and MHC antibodies are critical in Immunopeptidomics, aiding in identification and characterization of neoantigens through HPLC coupled to tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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