Thermo Fisher Scientific CD31 Monoclonal Antibody (MEM-05), FITC

Applications

Immunocytochemistry (ICC/IF)

• Tested dilution: Not specified
• View 1 publication

Flow Cytometry (Flow)

• Recommended use: 20 µg/100 µL whole blood or 10⁶ cells

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 488
• APC
• Biotin
• PE
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with an extracellular epitope of CD31 (PECAM-1), a 130–140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells, and stem cells of the myeloid lineage.

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling via dual ITIM motifs. It is expressed ubiquitously within the vascular compartment, mainly at junctions between adjacent cells. The N-terminal Ig-like domain mediates homophilic binding, crucial for cell-cell interactions.
CD31 plays diverse roles in:

• Integrin-mediated cell adhesion
• Transendothelial migration
• Angiogenesis
• Apoptosis
• Regulation of immunoreceptor signaling
• Autoimmunity and thrombosis

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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