Thermo Fisher Scientific NUP88 Polyclonal Antibody
Human NUP88 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot에 최적화됨. 항원 친화 크로마토그래피로 정제되어 순도 95% 이상. 액상 형태로 1 mg/mL 농도, PBS/glycerol buffer에 보존. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 399–444 of human NUP88 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553860 |
Product Specific Information
- Detects endogenous NUP88 protein at a molecular weight of 88 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), characterized by O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG).
Nup88 (nucleoporin 88 kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. Expressed ubiquitously, Nup88 is phosphorylated by ATM or ATR and upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis.
The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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