Thermo Fisher Scientific NUP88 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

• Detects endogenous NUP88 protein at a molecular weight of 88 kDa.
• Purity is >95% by SDS-PAGE.

Target Information

The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), characterized by O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG).
Nup88 (nucleoporin 88 kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. Expressed ubiquitously, Nup88 is phosphorylated by ATM or ATR and upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis.
The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.