Thermo Fisher Scientific Phospho-Occludin (Tyr287) Polyclonal Antibody
Phospho-Occludin (Tyr287) 특이적 폴리클로날 항체로, 인간·마우스·랫트 시료에서 인산화된 Occludin 검출에 적합. Western blot 및 IHC(P) 검증 완료. PBS/glycerol 용액 형태로 -20°C 보관. 연구용으로만 사용 가능.
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- PA5105344
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human OCLN (Accession Q16625), corresponding to amino acid residues around phosphorylated Tyr287 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816772 |
Product Specific Information
This antibody detects endogenous levels of Occludin only when phosphorylated at Tyr287.
Target Information
Occludin is a 65 kDa protein that can exist in various phosphorylated forms, up to approximately 82 kDa. It plays a role in regulating both the localization and function of tight junctions. Polyunsaturated fatty acids up-regulate occludin expression, enhancing transendothelial resistance and reducing macromolecular permeability. Expression levels vary by tissue — high and continuous in brain cell junctions, lower and discontinuous in non-neural tissues. Structural features of occludin are highly conserved across species. Under-expression of occludin and other tight junction proteins contributes to increased permeability in tumor endothelial junctions, associated with brain tumor edema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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