Thermo Fisher Scientific Factor X/Xa Polyclonal Antibody

Thermo Fisher Scientific Factor X/Xa Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: rat liver, human F10-transfected 293T cells
• Predicted reactivity: Rhesus Monkey (93%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by one or more disulfide bonds; the light chain contains two EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to other hemostatic serine proteases.
The mature factor is activated by cleavage of the activation peptide by factor IXa (intrinsic pathway) or by factor VIIa (extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca²⁺, and phospholipid during blood clotting.
Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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