Thermo Fisher Scientific c-Myc Chimeric Recombinant Human Monoclonal Antibody (9E10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Specificity: Epitope sequence EQKLISEEDL located in aa 410–419 of human c-Myc protein.

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is functionally associated with cell proliferation and regulation. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.

The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation, while deregulated expression induces apoptosis in multiple cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags at either terminal of target proteins.

c-Myc, N-Myc, and L-Myc proteins are involved in cell proliferation, differentiation, and neoplastic disease. Amplification of the c-Myc gene has been observed in human tumors such as lung, breast, and colon carcinomas. N-Myc amplification is characteristic of neuroblastomas.

Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is associated with Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-Myc expression is found in diverse tumors including colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.