Thermo Fisher Scientific NAE1 Monoclonal Antibody (OTI1A8), TrueMAB
NAE1 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI1A8). Western blot에 최적화되어 있으며, Human 시료에 반응. Lyophilized 형태로 공급되며, PBS buffer(pH 7.3, 8% trehalose) 포함. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–274 of human NAE1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The protein encoded by the NAE1 gene binds to the beta-amyloid precursor protein, which is a cell surface protein with signal-transducing properties and is implicated in the pathogenesis of Alzheimer’s disease.
This protein forms a heterodimer with UBE1C, binds and activates NEDD8 (a ubiquitin-like protein), and is required for cell cycle progression through the S/M checkpoint.
Three transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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