Thermo Fisher Scientific NAE1 Monoclonal Antibody (OTI1A8), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The protein encoded by the NAE1 gene binds to the beta-amyloid precursor protein, which is a cell surface protein with signal-transducing properties and is implicated in the pathogenesis of Alzheimer’s disease.
This protein forms a heterodimer with UBE1C, binds and activates NEDD8 (a ubiquitin-like protein), and is required for cell cycle progression through the S/M checkpoint.
Three transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.