Thermo Fisher Scientific p130Cas Monoclonal Antibody (M144)
p130Cas 단백질을 검출하는 Mouse monoclonal antibody (Clone M144). Western blot, IHC, ICC, IP 등 다양한 응용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 액상 형태로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:250 |
| Immunocytochemistry (ICC/IF) | 1:250 |
| Immunoprecipitation (IP) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M144 |
| Immunogen | Clone M144 was generated from a recombinant protein containing amino acid residues in the C-terminal region of rat p130 Cas. This rat sequence is highly conserved in human, mouse, and chicken p130 Cas. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.0625 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942656 |
Product Specific Information
The antibody detects a 130 kDa protein corresponding to the molecular mass of p130 Cas on SDS-PAGE immunoblots of human A431, endothelial, and Hct116 cells.
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signals via v-Crk and v-Src oncoproteins. It contains a Src homology (SH)-3 domain, multiple YXXP motifs, and a proline-rich region. p130Cas is involved in biological processes such as cell adhesion, migration, growth factor stimulation, cytokine receptor engagement, and bacterial infection. Physiological roles include cardiovascular development, actin filament assembly, and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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