Thermo Fisher Scientific TANK Polyclonal Antibody
TANK 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western blot, IHC, Flow cytometry에 사용 가능하며, 고순도의 Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 88–114 amino acids from the central region of human TANK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543254 |
Target Information
TANK was initially identified as a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Ligand binding by surface receptors in the TNF receptor and Toll/interleukin-1 receptor families leads to the formation of a TRAF/TANK complex that mediates activation of NF-kappa-B through association with kinases IKK-iota and TBK1. These proteins can form a complex with NEMO, which regulates the Ikappa-B complex, suggesting TBK1 and IKK-iota may modulate NF-kappa-B transactivation potential. At least two isoforms of TANK are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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