Thermo Fisher Scientific HMGCR Recombinant Rabbit Monoclonal Antibody (ARC0496)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0496

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 400-500 of human HMGCR (P04035) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HMGCR,uniProtId:P04035-1,ncbiNodeId:9606,antigenRange:400-500,antigenLength:888,antigenImageFileName:MA5-35242_HMGCR_P04035-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35242_HMGCR_P04035-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849145

Product Specific Information

Immunogen sequence: IKPLVAETDT PNRATFVVGN SSLLDTSSVL VTQEPEIELP REPRPNEECL QILGNAEKGA KFLSDAEIIQ LVNAKHIPAY KLETLMETHE RGVSIRRQLL S

Target Information

3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.