Thermo Fisher Scientific LIMP2 Recombinant Rabbit Monoclonal Antibody (052)

Applications and Tested Dilution

Product Specifications

Additional Formats

• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Mouse LIMP-2/SCARB2/CD36L2.

Target Information

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene. SR-BII differs from SR-BI in its c-terminal cytoplasmic domain and binds HDLs with approximately 4-fold lower efficiency.

SR-BII is abundant in mouse tissues expressing SR-BI, including liver, adrenal glands, and testes. Although its role is not completely clear, SR-BII may function as an HDL receptor. SR-BII mRNA results from alternative splicing of SR-BI precursor transcripts, mediating selective lipid transfer between HDL and cells. The relative expression and functional activities of these isoforms may regulate selective lipid transfer between HDL and cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.