Thermo Fisher Scientific p53R2 Monoclonal Antibody (11)
Human RRM2B/p53R2 단백질을 인식하는 Mouse Monoclonal Antibody로, ELISA에 적합하며 보존제가 없는 고순도 제품입니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로 DNA 손상 복구 및 p53 신호전달 연구에 활용됩니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 1:250–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 11 |
| Immunogen | Recombinant Human RRM2B/P53R2 Protein (Met1–Phe351) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785599 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human RRM2B/P53R2.
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several molecules involved in p53 signaling—including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2—were recently discovered.
p53R2 is a p53-inducible gene containing a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. It is induced by ultraviolet and gamma irradiation that cause DNA damage. The p53R2 gene product is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression.
p53R2 is an important target of p53 for tumor suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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